منابع مشابه
Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation.
Deficient immunoregulation by CD4+ T cells is an important susceptibility trait for inflammatory bowel disease, but the role of other regulatory cell types is less understood. This study addresses the role and mechanistic interaction of B cells and CD8+ T cells in controlling immune-mediated colitis. The genetic requirements for B cells and CD8+ T cells to confer protective immunoregulation wer...
متن کاملHistidine-rich glycoprotein blocks T cell rosette formation and modulates both T cell activation and immunoregulation.
Histidine-rich glycoprotein (HRGP) is a plasma and platelet protein with undefined function in vivo. It has been reported to inhibit rosette formation between murine T cells and erythrocytes. We have shown that HRGP binds specifically to human T lymphocytes but not sheep erythrocytes and have demonstrated a 56-kDa HRGP-binding protein on the T cell surface which is distinct from the CD2 sheep e...
متن کاملExtracellular purines and their receptors in immunoregulation
T cells are important effector cells in natural antiviral and anticancer immunity. It is important to reveal the cellular and molecular requirements for T cell differentiation and effector functions. We explored the idea that the final outcome of antigen receptor-driven immune processes is at least partially determined by physiologically abundant small signaling molecules in extracellular envir...
متن کاملIntroduction: immunoregulation: harnessing T cell biology for therapeutic benefit.
Of the various organ systems within the human body, the immune system is arguably the most powerful. The potential to destroy specific targets is combined with an exquisite ability to discriminate between ‘self ’ and ‘non-self ’, where destructive activity is limited to foreign targets including pathogenic microorganisms, genetically disparate cells, and certain cancer cells. Occasionally, immu...
متن کاملAn integrated view of suppressor T cell subsets in immunoregulation.
The immune system evolved to protect organisms from a virtually infinite variety of disease-causing agents but to avoid harmful responses to self. Because immune protective mechanisms include the elaboration of potent inflammatory molecules, antibodies, and killer cell activation--which together can not only destroy invading microorganisms, pathogenic autoreactive cells, and tumors, but also mo...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1985
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107688507801219